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KMID : 0895820170270040085
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Journal of Oriental Rehabilitation Medicine
2017 Volume.27 No. 4 p.85 ~ p.96
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Systematic Review on Traditional Chinese Herbal Medicine Treatment for Antibiotic Associated Diarrhea
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Chang Se-Ju
Lee Myeong-Jong
Kim Ho-Jun
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Abstract
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Objectives: To summarize and evaluate the efficacy of traditional Chinese herbal medicine (TCHM) treatment for antibiotic associated diarrhea (AAD).
Methods: Eight electronic databases were searched from their inception to August 2017. Randomized controlled trials (RCTs) assessing the efficacy of TCHM treatment for AAD were included. The risk of bias was assessed using the Cochrane risk of bias assessment tool. Data analysis was performed using RevMan software version 5.3.
Results: Seventeen RCTs involving 1138 patients with AAD were included for qualitative synthesis. TCHM treatment improved total effective rate (TER). However, the results that TER in experimental group was significantly higher than in control group were different between the included studies. TCHM enema treatment improved TER, but not significantly higher than control group. The most frequently used herbal formulas were Gamiwekwanjeon, Gamiinsampaedoksan, and Samryungbaekchulsan. The most frequently used TCHMs were Atractylodes macrocephala (Bai Zhu), Dioscorea batatas (Shan Yao). Within the studies documenting the adverse events, no serious adverse events associated with TCHM treatment were observed.
Conclusions: Evidence of TCHM treatment efficacy for AAD is encouraging, but not conclusive, because of the low methodological qualities, diversity of TCHM treatment prescriptions. Further well-designed RCTs with rigorous randomization and blinding method are needed to confirm these results.
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KEYWORD
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Antibiotic associated diarrhea , Clostridium difficile , Herb , Traditional Chinese medicine
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